As part of the agreement, Sheba medical Center will provide Skip Therapeutics with its de-identified patient mutation repository. Credit: ldutko / Shutterstock.com.

Israel-based Skip Therapeutics and Sheba Medical Center in Ramat Gan have joined forces on the development of RNA-based treatments, specifically antisense oligonucleotide (ASO) therapies, for rare genetic diseases.

As part of the agreement, Sheba will provide Skip with its de-identified patient mutation repository, and Skip Therapeutics will conduct a bioinformatic assessment to determine the feasibility of using ASOs.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

The Israeli company leverages its proprietary bioinformatic engine to pinpoint the most promising ASO-based molecular strategies tailored to specific patient sub-populations based on their unique mutations.

Skip Therapeutics chief scientific officer Ariel Feiglin said: “Recent advancements in RNA-therapeutics offer an expanded molecular toolkit that can be deployed rapidly and at relatively low costs to restore protein function of mutated genes.

“This presents exciting possibilities of drug development for small patient cohorts and eventually even for single patients.

“To effectively realise these possibilities, it is necessary to incorporate computational tools in the developmental process, and we believe that our computational approach will enable an effective and rapid development of ASO-based treatments.”

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The move is expected to bypass the mutations, restore protein function, and establish effective therapeutic approaches for rare diseases.

Currently, Skip Therapeutics is identifying targets and conducting in-vitro functionality studies in collaboration with various hospitals and academic institutes worldwide.

Sheba Medical Center haematology laboratory director Dr Dan Dominissini said: “Skip Therapeutics’ novel computational engine will enable us not only to determine the most appropriate therapeutic design for a given genetic disease but also to directly identify treatable patient populations, thereby maximising efficiency and minimising costs.

“We look forward to propelling gene therapy forward as a result of this exciting collaboration.”