Riptide Bioscience has signed a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI), a part of the National Institutes of Health in the US. 

The agreement is for three years and is entitled, 'Evaluation of Riptide Bioscience's Proprietary Peptide RP-182 in Preclinical Studies for the Treatment of Pancreatic Cancer. 

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Research under the CRADA generates data to support an Investigational New Drug filing of this agent with the US FDA.

Pancreatic cancer is a lethal diseases – 90% of patients die within one year of diagnosis. 

Even following surgical removal of the primary tumor, long-term survival rates are poor, with tumors recurring in virtually all patients. 

 Riptide Bioscience executive vice president Henry Lopez stated: "We're delighted to finalize this agreement with NCI and believe it is an important affirmation of the strength of Riptide's research program. 

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"Our development team has already been working closely with NCI for several years, and NCI scientists have had an opportunity to test RP-182 in transgenic models of pancreatic tumors, with significant success.  

"RP-182strongly complements the effectiveness of chemotherapies such as gemcitabine, substantially arresting tumor growth and extending survival."

Lopez continued, "We believe that RP-182 will prove to be complementary to both conventional chemotherapies and emerging immunotherapies.  RP-182 alters the balance of cell populations in the tumor microenvironment so as to become tumor-inhibiting rather than tumor-promoting.  We think this approach has real potential to become the 'third leg' of a therapeutic tripod that currently includes chemotherapy and immunotherapy."

The National Cancer Institute's team on the RP-182 project comes from the Thoracic and Gastrointestinal Oncology Branch, in the Center for Cancer Research, Bethesda, Maryland. 

The NCI team is headed by Dr. Udo Rudloff, a physician scientist with both research and patient-care responsibilities.